Pro-Resolving Mediators (SPMs) in Biology:

SPMs hold immense potential for various areas of biology, offering exciting perspectives for:

1. Understanding and Treating Inflammation:

• Resolution Phase: They illuminate the natural “resolution phase” of inflammation, crucial for tissue healing and preventing chronic inflammation associated with diseases like asthma, atherosclerosis, and arthritis.
• Targeted Approach: Unlike broad-spectrum anti-inflammatory drugs, SPMs offer a more targeted approach, promoting resolution while preserving beneficial aspects of inflammation like pathogen clearance.
• New Therapeutic Targets: Studying SPMs helps identify novel therapeutic targets for developing drugs that promote natural resolution pathways.

2. Tissue Regeneration and Repair:

• SPM Signaling: Research explores how SPM signaling promotes tissue repair and regeneration after injury or disease. For example, SPMs stimulate stem cell recruitment and activity, enhancing tissue healing.
• Applications: This knowledge could lead to SPM-based therapies for wound healing, organ transplantation, and degenerative diseases.

3. Infections and Antimicrobial Resistance:

• Modulating Immune Response: SPMs can modulate the immune response during infections, promoting efficient pathogen clearance while reducing tissue damage.
• Combating Resistance: They might offer strategies to combat antimicrobial resistance by enhancing phagocytosis and bacterial killing by immune cells.
• Anti-inflammatory Properties: The anti-inflammatory properties of SPMs could help manage inflammatory complications associated with infections.

4. Neurological Disorders:

• Neuroinflammation: SPMs show promise in reducing neuroinflammation, a key factor in neurodegenerative diseases like Alzheimer’s and Parkinson’s.
• Neuroprotective Effects: Studies suggest their neuroprotective effects by promoting neuronal survival and regeneration.
• Development of Treatments: This research lays the groundwork for developing SPM-based treatments for neurological disorders.

5. Beyond Inflammation:

• Cancer: Research explores the potential role of SPMs in regulating tumor growth and metastasis.
• Fibrosis: Understanding how SPMs modulate tissue repair could help prevent excessive fibrosis associated with various diseases.
• Metabolic Disorders: Studies examine the possible involvement of SPMs in metabolic disorders like obesity and diabetes.

Overall:

Understanding and harnessing the power of SPMs is a blooming field in biology with the potential to revolutionize treatment approaches for diverse diseases and conditions. Research continues to unveil their multifaceted roles and pave the way for innovative therapeutic strategies based on these natural resolution pathways.

Advanced ReSolve & ReStore™ is a highly concentrated fish oil with a standardized quantity of the pro-resolving mediators (PRMs) 18-HEPE, 17-HDHA, and 14-HDHA. Metabolites of PRMs, known as specialized PRMs, provide building blocks to support the natural resolution of the immune response.*

Directions:

Take one softgel daily, or use as directed by your healthcare professional.

Consult your healthcare professional before use. Individuals taking blood thinners or other medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

         

         Soy                      Egg               Gluten                Shellfish               Yeast            Tree Nuts

      

    Corn                    Wheat                Dairy              Peanuts              Sesame

Storage:

Keep closed in a cool, dry place out of reach of children.

Does Not Contain:

Wheat, gluten, corn, yeast, soy, dairy products, crustacean shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Other Ingredients:

Softgel (bovine gelatin, glycerin, purified water), and natural lemon flavor.

Contains:

Fish (anchovy, sardine, herring, and mackerel) and squid.

Trademarks:

Arctic Oils is a registered trademark of XYMOGEN, Inc.